As lifespan are getting longer,age-related neurodegenerative disease such as Alzheimers disease(AD) has become one of the most devastating diseases.Drug development based on blocking amyloid cascade is the mainstream strategy in recent decade.The biometal dyshomeostasis like Cu2+ and Zn2+ were regarded as important cofactors of amyloid cascade in AD.Thus,up to now,there are no compounds in the clinical trial targeting on Aβ demonstrate significant benefits in cognitive improvement.Therefore,we designed and synthesized a multifunctional lead compound that could interact with metal resulting in anti-Aβ aggregation,ROS elimination and neurotrophic activities.