【摘 要】
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In recent years much attention has been focused on using alcohols as begin alkylating reagents because they are much greener chemicals than the corresponding more active alkyl halides or carbonyl comp
【机 构】
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College of Chemistry and Materials Engineering Wenzhou University, Wenzhou, Zhejiang 325035
【出 处】
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中国化学会第十三届全国有机合成化学学术研讨会
论文部分内容阅读
In recent years much attention has been focused on using alcohols as begin alkylating reagents because they are much greener chemicals than the corresponding more active alkyl halides or carbonyl compounds,with relatively higher atom efficiency achievable by producing water as the only by-product.1 Among the researches,several transition metal (ruthenium,iridium,palladium,and etc.)-catalyzed anaerobic dehydrogenative alcohol activation methods have also been developed for β-C-alkylation of secondary alcohols to achieve alkylated ketones.2 However,these methods still have some drawbacks such as the use of expensive and toxic rare metal complexes or ligands,large amounts of hydrogen acceptor and/or bases,as well as inert conditions.In the past few years,our group has concentrated on C-,N-and O-alkylation reactions.3 We now developed a new simple and practical method for transition metal-free synthesis of alkylated ketones by direct dehydrative β-C-alkylation of secondary alcohols with primary alcohols under aerobic conditions.
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