7,8-二羟基黄酮逆转精神分裂症模型大鼠认知功能及海马突触可塑性损伤

来源 :2014中华医学会第十二次全国精神医学学术会议 | 被引量 : 0次 | 上传用户：blnxy325

【摘要】

：

目的认知功能损害是精神分裂症独立于阳性和阴性症状的第三大核心症状,对患者社会功能和总体疗效具有重要影响,但目前尚缺乏有效治疗手段.大量研究发现,脑源性神经营养因子(BDNF)及其TrkB受体功能异常是精神分裂症认知损害的重要病理基础.7,8-二羟基黄酮(7,8-DHF)是近年来新发现的特异性TrkB受体激动剂,具有良好的血脑屏障通透能力.本研究探讨7,8-DHF对精神分裂症模型大鼠海马相关认知功

【作者】

：

杨远坚李炎坤王伟胡茂荣余斌胡斌

【机构】

：

江西省精神病院湖北科技学院药学院

【出处】

：

2014中华医学会第十二次全国精神医学学术会议

【发表日期】

：

2014年3期

下载到本地 , 更方便阅读

下载此文赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

其他文献

Correlation between Levels of Exhaled Hydrogen Sulfide and Airway Inflammatory Phenotype in Patients

Background and objective Endogenous hydrogen sulfide (H2S) constitutes a biomarker of.asthma severity and activity.However, the relationship between exhaled H2S and airway inflammation phenotypes in a

会议

The lateral habenular nucleus mediates the control of 5-HT release by insular cortex in the raphe nu

Investigate the role of the Hb and the Ic in OSA and the functional relationship.Stimulating the INS of Wistar rats, and compared the results with the control group.Stimulation the INS caused respirat

会议

Prenatal chronic intermittent hypoxia leads to early atherosclerotic lesions and upregulates Caveoli

Objective Chronic intermittent hypoxia (CIH) has been associated with atherosclerotic lesions.However,whether prenatal exposure to CIH causes atherosclerosis after birth is unclear.

会议

Insulin-like Growth Factor-1 (IGF-1) Up-regulates Surfactant Protein-B (SP-B) through GSK-3β/β-cante

Rationale and Objective Pulmonary edema and compromised lung compliance, resulting from the reduction of pulmonary surfactant (PS), were the most important features in the early stage of ALI/ARDS.

会议

Different hypoxia patterns induce different expression of Na+/H+ exchanger isoform 3 in adult rat me

Objective The present experiments were carried out to investigate the expression of Na+/H+ exchanger isoform 3(NHE3) in medulla oblongata of rats and effects of different hypoxia patterns (intermitten

会议

Appropriate Pronase Digestion Time is Essential for Culture and Differentiation of Primary Mouse Tra

Objective The protocol for culture and differentiation of primary mouse tracheal epithelial cells (MTECs) has been established by many researchers.It is acknowledged to detach cells from mouse trachea

会议

Erythromycin and dexamethasone decrease IL-8 in U937 cells treated with cigarette smoke extract by i

Corticosteroid insensitivity, which is induced by cigarette smoke extract (CSE), is a significant barrier when treating chronic obstructive pulmonary disease (COPD).

会议

The interventional effect of reduced glutathione against intermittent hypoxia-induced ultrastructura

Background Intermittent hypoxia (IH), as a major characteristic of obstructive sleep apnea, may represent a chronic intermittent stress, leading to dysregulation of hypothalamic-pituitary-adrenal (HPA

会议

Utility of endobronchial ultrasound-guided transbronchial needle aspiration in patients with non-spe

Background and objective Endobronchial ultrasound-guidedtransbronchial needle aspiration (EBUS-TBNA) has emerged as a minimally invasive technique used for diagnosing intrathoracic malignancies as wel

会议

酒精性肺疾病的临床研究及进展

酒精对全身器官均有损害,随着研究的深入,酒精性肺疾病逐渐被人们重视.基于酒精的挥发性和肺脏的丰富血供,酒精可以通过支气管循环从纤毛上皮进入到气道,汽化的滔精还可以沉积回气道随呼气再次被释放,这种重复循环使局部气道上皮细胞持续暴露于高浓度酒精下.

会议

7,8-二羟基黄酮逆转精神分裂症模型大鼠认知功能及海马突触可塑性损伤

与本文相关的学术论文