论文部分内容阅读
ACK1 promotes migration and invasion through the FAK-AKT-POU2F1-ECD signaling axis in gastric cancer
【机 构】
:
广州医科大学附属第三医院生物医学研究中心(中心实验室),广州 510150;暨南大学生科院/生命与健康工程研究院,广州 510632
【出 处】
:
中国病理生理学会第十四届肿瘤专业委员会、第十五届免疫专业委员会联合学术会议
【发表日期】
:
2014年4期
其他文献
目的:EB病毒是一种人类疱疹病毒,与多种淋巴增生性疾病如传染性单核细胞增多症和淋巴瘤以及鼻咽癌等恶性肿瘤密切相关.EB病毒对于上皮细胞和淋巴细胞的恶性转化作用与其潜伏状态密切相关.本研究将探讨miR-18a在EBV感染及其在淋巴瘤发生发展中的作用.紫外照射和缺氧是病毒感染的重要影响因素.本研究将探讨miR-18a在紫外照射和缺氧条件下对于EBV感染的影响。方法:体外培养BJAB,P3HR1,RAJ
OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT v
PURPOSE:Emerging evidence has indicated that the expression of opioid binding protein/cell adhesion molecule-like (OPCML) gene is frequently altered in a variety of cancers.We previously demonstrated
Next-generation methylation sequencing of breast cancer candidate genes using nanofluidic-PCR prepar
The epigenetic silencing of tumor suppressor gene PAX5 is involved in tumorigenesis of human non-sma
Aim: Recent studies have suggested that the paired box 5 (PAX5) gene is connected with tumorigenesis of a wide variety of tumors.However,the link between PAX5 and non-small cell lung cancer (NSCLC) re
Objective: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors.Annually,there are over 0.5 million new patients worldwide and more than half of the new cases occur in China.HCC i
The release of Hox stalled genes via the TET3 pathway by oncoprotein LMP1 in response to radiation i
Epstein-Barr virus (EBV) causes human lymphoid malignancies and epithelial carcinomas including nasopharyngeal carcinoma (NPC),and the EBV product latent membrane protein 1 (LMP1) has been identified
目的:寻找新的肿瘤相关抗原和具有临床价值的分子标记物,并研究该分子标记物在不同肿瘤发生发展中的作用,探究其表达水平与结直肠癌、乳腺癌两种肿瘤患者生存预后的关联
。方法:通过噬菌体展示肽库筛选与结直肠癌患者血清中抗体特异性结合的多肽,根据同源性分析和三维结构模拟获得抗原蛋白并制备其抗体.通过免疫组化检测结直肠癌与乳腺癌患者中该蛋白的表达水平,用Kaplan-Meier曲线和Cox多因素风险模型判断其
目的:阐明UBE2L6基因在鼻咽癌中表达失活的机制,探讨其抑制肿瘤的分子机制。方法:应用半定量RT-PCR及免疫组化技术评价UBE2L6在鼻咽癌中的表达水平.利用甲基化特异性PCR及亚硫酸氢盐测序法检测UBE2L6基因DNA启动子区甲基化程度.以细胞生长曲线,克隆形成,流式细胞术方法评价UBE2L6基因如何影响鼻咽癌细胞系的生物学行为.采用BODIPY荧光脂质染料评价细胞内脂肪滴含量.通过免疫共沉
A novel AP-1/miR-101 regulatory feedback loop and its implication in the migration and invasion of h
MicroRNA-101 (miR-101) is frequently downregulated in various cancers.To date,the regulatory networks of miR-101 remain obscure.In this study,we demonstrated that miR-101 was mainly transcribed from h
会议
A549 escape from cytotoxicity of 5-FU and acquire malignant phenotype through consecutively undergoi
Epithelial-mesenchymal transition (EMT) and mesenchymal-epithelial transition (MET) are two crucial steps during tumor metastasis.Some evidences demonstrate chemotherapy could induce epithelial-mesenc