【摘 要】
：
The spirooxindole scaffolds are the structural centerpieces of a large number of alkaloids and unnatural compounds which exhibit pronounced biological and medicinal activities.[1-3] In the past few ye
【机 构】
：
Key Laboratory of Synthetic Chemistry of Natural Substances,Shanghai Institute of Organic Chemistry,
【出 处】
：
The 24th International Society of Heterocyclic Chemistry Con
论文部分内容阅读
The spirooxindole scaffolds are the structural centerpieces of a large number of alkaloids and unnatural compounds which exhibit pronounced biological and medicinal activities.[1-3] In the past few years, a flourish of asymmetric reactions targeting the construction of highly strained chiral spirooxindole structures have been witnessed.[4] An efficient organocatalytic aza/oxa/thia-MichaelMichael cascade reaction for the asymmetric synthesis of highly functionalized spirooxindole tetrahydroquinolines, chromans and tetrahydrothiophenes scaffolds has been reported through a formal [4/3+2] annulation strategy.
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