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To identify genes related to aging, we systematically characterized 32 mouse inbred strains in longitudinal and cross sectional study designs.We observed significant correlations of both the age of female sexual maturation (FSM) and circulating IGF1 at 6 months with longevity.We further found that C57BL/6J females had 9% lower IGF1, 6% delay in age of sexual maturation and 24% extended longevity compared to a congenic strain, which carries a C3H/HeJ allele on C57BL/6J background.