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Mitogen-activated protein kinases/Extracellular signal-regulated kinase (MAPK/ERK) pathway is essential for migratory and invasive properties of malignant glioma.Targeting this pathway was shown to be efficient to inhibit migration and invasion of glioma cells.High dose of oleanolic acid (OA) has been widely demonstrated to suppress survival,growth and angiogenesis of glioma cells.In this study,we found that OA significantly decreased the ability of glioma cells to migrate and invade even at low dose where their survival and growth were not affected.Multiple pathwayscreening showed that activation of MAPK/ERK pathway was greatly inhibited under low concentration of OA treatment.Further immunoblotting assays confirmed that MAPK/ERK signaling was blocked by OA in glioma cells.