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目的:建立甲亢阴虚证大鼠模型。方法:取SD大鼠雌雄,分别随机分为4组,共8组,每组6只,分别为空白对照组、甲状腺片生理盐水混悬液低、中、高剂量组。空白对照组灌胃给予等体积的生理盐水,各给药组组分别给予浓度为2.5、5、10 mg/kg的甲状腺片生理盐水混悬液,1次/d,连续给药30 d。结果:给药组与空白对照组比较,除高剂量组雌性大鼠血清T3、T4、FT3、FT4值显著升高(P<0.01),血清TSH值显著降低(P<0.05)外,其余组均无显著性差异(P(0.05)。说明高剂量组雌性大鼠造模成功。结论:灌服甲状腺片混悬液10 mg/kg,连续给药30 d的雌性大鼠甲亢阴虚证大鼠模型制备成功。
Objective: To establish a rat model of hyperthyroidism and Yin deficiency. METHODS: Male and female SD rats were randomly divided into 4 groups, a total of 8 groups, 6 in each group. They were blank control group, thyroid tablets, normal saline suspension low, middle and high dose groups. The control group was given intragastric administration of an equal volume of normal saline, and each administration group was given a suspension of thyroid tablets at a concentration of 2.5, 5, and 10 mg/kg once a day for 30 days. RESULTS: Compared with the blank control group, serum T3, T4, FT3, and FT4 levels in the female rats of the high-dose group were significantly higher (P<0.01), and serum TSH levels were significantly lower (P<0.05). There was no significant difference between the two groups (P(0.05). It indicated that the female rats in the high-dose group had a successful model. Conclusion: The thyroid tablet suspension 10 mg/kg, 30 days after continuous administration, the female hyperthyroidism deficiency syndrome The rat model was successfully prepared.