Regioselective Arylation of Uracil and 4-Pyridone Derivatives via Copper(Ⅰ) Bromide Mediated C-H Bon

来源 :The 24th International Society of Heterocyclic Chemistry Con | 被引量 : 0次 | 上传用户：boysunshine20xy

【摘要】

：

A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(Ⅰ

【作者】

：

Chien Cheng Yu-Chiao Shih Hui-Ting Chen Tun-Cheng Chien

【机构】

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DepartmentofChemistry,NationalTaiwanNormalUniversity,Taipei11677DepartmentofFragranceandCosmeticScie

【出处】

：

The 24th International Society of Heterocyclic Chemistry Con

【发表日期】

：

2013年9期

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A series of 6-aryl-1,3-dimethyluracils were synthesized from the reaction of 1,3-dimethyluracil with various phenyl iodides in DMF, in the presence of copper(Ⅰ) bromide as the catalyst and lithium t-butoxide as the base.This methodology is applicable to a variety of 5-substituted uracils as well as 4-pyridone to provide direct accesses to versatile uracil and 4-pyridone derivatives.

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Regioselective Arylation of Uracil and 4-Pyridone Derivatives via Copper(Ⅰ) Bromide Mediated C-H Bon

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