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Objective: Recent evidence suggests a strong link between erectile dysfunction(ED)and metabolic syndrome/cardiovascular disease.We sought to investigate male erectile function of hospitalized patients with metabolic syndrome/cardiovascular disease and the incidence of ED and explore the relationship between metabolic syndrome/cardiovascular disease as well as its risk factors and ED.Methods: Male patients with diabetes/metabolic syndrome and cardiovascular disease,hospitalized in the department of endocrinology and cardiology of the First Affiliated Hospital of Xi'an Jiaotong University were inquired by using an designed questionnaire.Body height,weight,waist circumference,hip circumference were recorded;erection function of patients were scaled by IIEF-5.Uni-/Multivariable Logistic regression and OR analysis were employed to evaluate the risk factor of ED.Results: Statistic shows the incident rate of ED is 90.86%and 66.7%hospitalized patients with metabolic syndrome/cardiovascular disease respectively.Univariate Logistic regression shows the risk factor of cardiovascular patient suffering ED are: age,smoking,BMI,total cholesterol,TC/HDL,Hypertension and CAD.Multivariable Logistic regression shows the risk factor of cardiovascular patient suffering ED are age,financial condition,smoking,BMI and TC/HDL.Univariate Logistic regression shows the risk factors of MetS patient suffering ED are age,salary,physical activity,course of diabetes,TG.Multivariable Logistic regression shows the risk factors of diabetes/MetS suffering ED are: age,course of diabetes,hypertension.Conclusions: The incidence of ED hospitalized patients with diabetes/MetS and cardiovascular disease are high and increasing by age.The risk factor of ED are course of diabetes,hypertension,smoking,BMI,total cholesterol,TC/HDL,Hypertension and CAD.