Intramolecular Regulation of the WW Domain of HYPB/SETD2 for Its Sequestration by the Huntingtin Agg

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：lqylzy

【摘要】

：

【作者】

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Yong-Guang Gao Hui Yang Jian Zhao Ya-Jun Jiang Hong-Yu Hu

【机构】

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State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, SIBS, CAS, Sh

【出处】

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中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

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2014年3期

【关键词】

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Huntingtin HYPB/SETD2 Intramolecular interaction Aggregate Sequestration Proline

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Huntingtons disease (HD) is a progressive neurodegenerative disorder caused by thepolyglutamine (polyQ) expansion in huntingtin (Htt) protein, a ubiquitously expressed proteinof yet unknown function.Given its public health importance,it is striking that thepathogenesis of HD is not well understood.

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Intramolecular Regulation of the WW Domain of HYPB/SETD2 for Its Sequestration by the Huntingtin Agg

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