【摘 要】
：
AIM: To probe the effect of Astragaloside Ⅳ and Ginsenoside Rg1 on autophagy injury of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R),as well as their interactions.METHODS: The a
【机 构】
：
Molecular Pathology Laboratory,Key Laboratory of Hunan Province for Prevention and Treatment of Inte
论文部分内容阅读
AIM: To probe the effect of Astragaloside Ⅳ and Ginsenoside Rg1 on autophagy injury of PC12 cell induced by oxygen glucose deprivation/reoxygenation(OGD/R),as well as their interactions.METHODS: The autophagy injury model of PC12 cell induced by OGD/R was established,Astragaloside Ⅳ and Ginsenoside Rg1 were divided into different dosages to interfere PC12 cell,the autophagosome was detected to assess the effect of drugs on the autophagy injury with confocal microsopy,the median inhibitory concentration(IC50)of Astragaloside Ⅳ and Ginsenoside Rg1 were calculate.
其他文献
Tremendous differences between human sexes are universally observed and accepted.Women and men show big differences in a diversity of characterics,from morphology to physiology,and from pathophysiolog
From androgenetic haploid blastocysts derived by injection of sperm into enucleated oocytes,we generate mouse androgenetic haploid embryonic stem cells(AG-haESCs)that can support full-term embryonic d
Spermatogonial stem cells(SSCs),namely male germline stem cells,are a subpopulation of type A spermatogonia capable of both self-renewing to maintain stem cell pool and differentiating into mature spe
A key step towards generating fertilization-competent eggs is the maturation of oocytes.Oocyte maturation encompasses integrated nuclear and cytoplasmic changes taking place during oocyte development,
Premature Ovarian Insufficiency(POI)is one of the most common reproductive disorders.However,the etiological causes of this disease still remain elusive.In this study,two novel mutations of WDR62 gene
Erythropoiesis is the process by which hematopoietic stem cells proliferate and differentiate through multiple stages to produce red cells.Dysregulation at any developmental stage will lead to anemia.
Germline activating mutations of protein tyrosine phosphatase PTPN11(Shp2),a positive regulator of the Ras signaling pathway,are associated with 50%of patients with Noonan syndrome.These patients have
Haematopoietic stem cells(HSCs)are derived early from embryonic precursors,such as haemogenic endothelial cells and pre-haematopoietic stem cells(pre-HSCs),the molecular identity of which still remain
The voltage sensor domain(VSD)consists of four transmembrane segments,serving as a voltage sensing module highly conserved among voltage-gated ion channels and voltage-sensing phosphatase(VSP).VSD-lik
Aim of study: To investigate the effects of the different proportion combinations between Astragalus and Angelica on bone marrow hematopoiesis suppression induced by Cyclophosphamide(CTX)in mice,furth