Increasing evidence suggests that carbohydrate-binding proteins play an essential role in tumor growth and metastasis.We have examined the role of galectin-3 in the regulation of pulmonary artery endothelial cell proliferation,migration,and neovascularization.Galectin-3,a multifunctional protein of an expanding family of β-galactoside-binding animal lectins,is the major nonintegrin cellular laminin-binding protein,and is implicated in a variety of biologic events,such as inflammation and angiogenesis.