Background: Preliminary data suggest that non-invasive methods could be useful to assess presence of oesophageal varices(OV) in liver cirrhosis.The primary objectives were to investigate non-invasive markers for diagnosing and grading OV in primary biliary cirrhosis.Methods: This study included a total of 106 consecutive treatment-naive patients with primary biliary cirrhosis(PBC).Results of physical examination,blood tests,and abdominal ultrasound scan (USS) were measured.Performance of non-invasive markers for OV was expressed as sensitivity,specificity,positive,and negative predictive values (PPV,NPV),accuracy,and area under the curve (AUC).