论文部分内容阅读
Objective To evaluate the effectiveness of the regimen that MA (methopterin+cytarabine) included in Hyper-CVAD/MA+ granulocyte colony-stimulating factor (G-CSF) on mobilization of hematopoietic stem cells in patients with malignant lymphoma.Methods The effects and safety of mobilizing haemopoietic stem cells in 11 patients with aggressive non-Hodgkin lymphoma (NHL) who were applied with MA+G-CSF regimen in our department from Jan.2006 to May 2010 were retrospectively analyzed.Results All the 11 patients were successfully collected by one time.The total number of colleted mononuclearcell (MNC) was (4.23±1.63)×108/kg and the total number of colleted CD34+ cells was (5.45±4.63)×106/kg.both of which satisfied the required number of stem cells.Adverse effects of mobilization process were small and the progress was easy to control.In addition.patients can tolerate this progress.After transplantation.except two cases of disease recurrence and death,seven patients showed complete remission.and the other two cases showed partial remission.Conclusion Mobilization of hemopoietic stem cells of patients with malignant lymphoma using MA+G-CSF regimen was not only safe.effective.and easy to operate.but also played the role of purging in vivo prior to transplantation.which attained two objectives by a single move.