Effect of glycine site/NMDA receptor agonist d-CyCloserine on opioid dependence

来源 :第十四届中国神经精神药理学学术会议 | 被引量 : 0次 | 上传用户:kedy830622
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  OBJECTIVE To investigate the effect of d-Cycloserine (DCS) on morphine-induced conditioned place preference (CPP) and heroin-induced self-administration (SA) for extinction and relapse.METHODS ① CPP mice were trained on a CPP procedure (4 morphine, 10 mg·kg-1, and 4 saline pairings with 1 of 2 compartments).Immediately follow ing the CPP test before all extinction training DCS 7.5, 15, 30 mg· kg-1 was ip given.
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