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  5. Id proteins are critical downstream effectors of BMPR-Ⅱ in pulmonary arterial smooth muscle cells

Id proteins are critical downstream effectors of BMPR-Ⅱ in pulmonary arterial smooth muscle cells

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：bpsend
【摘 要】
：
Aim: Bone morphogenetic protein type Ⅱ receptor (BMPR-Ⅱ) mutations are responsible for over 70％ of cases of heritable pulmonary arterial hypertension (PAH) and up to 15％-40％ of sporadic idiopathic dis
【作 者】
：
Xiao-hui LI Ying LI Yuan-jian LI 
【机 构】
：
Department of Pharmacology,School of Pharmaceutical Science,Central South University,Changsha 410078
【出 处】
：
The 12th Meeting of the Asia Pacific Federation of Pharmacol
【发表日期】
：
2013年4期
【关键词】
：
pulmonary hypertension BMPR-Ⅱ Id proteins PASMCs cell cycle 
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Aim: Bone morphogenetic protein type Ⅱ receptor (BMPR-Ⅱ) mutations are responsible for over 70％ of cases of heritable pulmonary arterial hypertension (PAH) and up to 15％-40％ of sporadic idiopathic disease.Loss of BMP signalling promotes pulmonary vascular remodelling via modulation of pulmonary artery smooth muscle cell (PASMC) migration, differentiation and proliferation.
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