【摘 要】
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Ketoprofen is a commonly used non-steroidal anti-inflammatory drug (NSAID).It exists in two isomic forms, namely, R and S enantiomers.While it is normally produced and marketed as the racemate, the op
【机 构】
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College of Chemistry and Material Engineering, Wenzhou University, Wenzhou 325035, China
【出 处】
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第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
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Ketoprofen is a commonly used non-steroidal anti-inflammatory drug (NSAID).It exists in two isomic forms, namely, R and S enantiomers.While it is normally produced and marketed as the racemate, the optically pure S-enantiomer (dexketoprofen), which is the major active component, is also available and proven to be more effective.Moreover, US FDA, in the middle of the last decade, began to encourage the assessments of each enantiomer activity for racemic drugs in body and promote the development of new drugs in single enantiomers.As a result, there is a need to develop an effective method for the separation of ketoprofen enantiomers.High-performance liquid chromatography (HPLC) is the most used analytical method for the profen separation.Simulated moving bed (SMB) technology, compared with the single stage HPLC, is a promising alternative due to its continuous operation and ability to realize complete separation for mixtures with low selectivity.
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