Dimer monomer transition and dimer re-formation play important role for ATM cellular function during

来源 :The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern | 被引量 : 0次 | 上传用户：something190

【摘要】

：

【作者】

：

Yingli Sun

【机构】

：

Beijing Institute of Genomics,Beijing,China

【出处】

：

The 16th Ataxia-Telangiectasia Workshop (ATW-2015)6th Intern

【发表日期】

：

2015年3期

【关键词】

：

ATM activation Intermolecular phosphorylation

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　　(1) Purpose: The ATM protein kinase, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks, mediates responses to ionizing radiation in mammalian cells.Although the downstream signaling pathway activated by ATM is well characterized, the mechanism of ATM activation in response to DSB remains to be elucidated.

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