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目的观察前列负阴方联合抗雄药物治疗晚期前列腺癌的临床疗效。方法将90例晚期前列腺癌患者随机分为治疗组(44例)和对照组(46例);两组均予化学抗雄药物治疗方案,治疗组同时加用前列负阴方。两组均以2个月为1个疗程,共治疗3个疗程,观察临床疗效及主要中医证候变化情况。结果治疗组、对照组总有效率分别为31.8%、30.4%;组间临床疗效比较,差异无统计学意义(P>0.05)。治疗前后组内比较,治疗组尿痛尿不适、神疲乏力、肢体疼痛、体质量减轻、自身总体评价评分差异有统计学意义(P<0.05),对照组恶心呕吐不思饮食、体质量减轻评分差异有统计学意义(P<0.05);组间治疗后比较,尿痛尿不适、恶心呕吐不思饮食、神疲乏力、肢体疼痛、体质量减轻、气短气急、自身总体评价评分差异有统计学意义(P<0.05)。结论前列负阴方联合去雄药物治疗晚期前列腺癌,可以明显提高患者的生活质量,改善临床症状。
Objective To observe the clinical effect of Qianlie Yin prescription combined with anti-male drug in the treatment of advanced prostate cancer. Methods Ninety patients with advanced prostate cancer were randomly divided into treatment group (n = 44) and control group (n = 46). Both groups were treated with chemical anti-androgen drugs. Two groups were 2 months for a course of treatment, a total of three courses of treatment to observe the clinical efficacy and changes in the main TCM symptoms. Results The total effective rates of the treatment group and the control group were respectively 31.8% and 30.4%. There was no significant difference in clinical efficacy between the two groups (P> 0.05). Before and after treatment in the treatment group, the urinary pain, urinary discomfort, Shenpi fatigue, limb pain, weight loss, the overall evaluation of the difference was statistically significant (P <0.05), the control group nausea and vomiting diet, weight loss There was statistically significant difference between the two groups (P <0.05). After treatment, urinary excretion and urine discomfort, nausea and vomiting did not think diet, Shenpi fatigue, limb pain, weight loss, shortness of breath and shortness of breath, Significance (P <0.05). Conclusions The treatment of advanced prostate cancer by the combination of negative yin side and progestational drugs can significantly improve the quality of life of patients and improve the clinical symptoms.