【摘 要】
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Background: Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein with molecular weight of 40 kDa.It is highly expressed in human epithelioma, but lowly expressed in normal
【出 处】
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中国免疫学会第九届全国免疫学学术大会
论文部分内容阅读
Background: Epithelial cell adhesion molecule (EpCAM) is a type I transmembrane glycoprotein with molecular weight of 40 kDa.It is highly expressed in human epithelioma, but lowly expressed in normal epithelial tissues.Objective: To construct an EpCAM-specific recombinant immunotoxin and further test its antitumor activity.Methods: The immunotoxin (GST-scFv2A9-PE or GST-APE) was constructed by genetically fusing a truncated form (PE38KDEL) of Pseudomonas aeruginosa exotoxin with an anti-EpCAM single chain fragment variable (scFv2A9).
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