Scale up of Membrane Chromatograpy for Biopharmaceutical Applications

来源 :2008中国深圳蛋白质和多肽科学大会 | 被引量 : 0次 | 上传用户:music5700
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  Adsorption chromatography is the predominant technique used in large-scale purification of bioproducts with ion-exchange being the most widely used technique.The chromatographer is faced with a variety of anion and cation exchange phases with a limited range of functional groups attached to a wider range of base matrices including sorbents for column applications,monoliths and membranes.The use of membranes as substrates for ion-exchange chromatography of biopolymers offers potential for exploitation of the very high usable flow rates and hence throughput potential that these units can sustain.
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