Signal adaptor sequestosomel/p62 normalizes proliferation of smooth muscle cells and remodeling of t

来源 :International Conference for Physiological Sciences 2012(201 | 被引量 : 0次 | 上传用户:fuchengjun007
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  A cytoplasmic adaptor protein sequestosomel/p62 (SQSTMI) plays a key role in receptor-mediated signaling and targeted degradation of ubiquitinated proteins through autophagy.SQSTM 1 is important in metabolic homeostasis/regulation and a phenotype of gene knockout mice is mature-onset obesity accompanied with related diseases, such as hypertension and steatosis.
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