【摘 要】
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This study evaluated neuroprotection by scorpion venom -derived polypeptide in early-stage Parkinsons disease rats induced by 6-hydroxydopamine.The early-stage Parkinsons disease was induced by inject
【机 构】
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Department of Physiology, Dalian Medical University, Dalian 116044, Liaoning Province, China
【出 处】
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第三届国际神经再生高峰论坛暨第五届脊髓损伤治疗与临床试验国际交流会(INRS2013 & 5th ISCITT)
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This study evaluated neuroprotection by scorpion venom -derived polypeptide in early-stage Parkinsons disease rats induced by 6-hydroxydopamine.The early-stage Parkinsons disease was induced by injections of 20 ug of 6-hydroxydopamine in 3 μL into the striatum.Rats were intraperitoneally administrated a scorpion venom-derived polypeptide (0.05 mg/kg per day) or relative vehicle for 1 week.The ultrastructure of mitochondria in the neurons of the substantia nigra was observed by electronic ultrastructure microscopy.The activities of monoamine oxidase-B,superoxide dismutase,and malondialdehyde in the mitochondria of neurons in the midbrain,as well as the inhibitory ability of hydroxyl free radical and the antioxidant ability of the serum were measured and used to evaluate the protective role of scorpion venom-derived polypeptide.Compared with untreated controls,scorpion venom-derived polypeptide treatment reduced the damage to mitochondrial ultrastructure in the neurons of the substantia nigra,reversed the abnormal activities of monoamine oxidase-B,superoxide dismutase,and malondialdehyde in the mitochondria of neurons in the midbrain,and improved the antioxidant ability of the serum in early-stage Parkinsons disease model rats.These findings indicate that scorpion venom-derived polypeptide may contribute to neuroprotection in a rat model of early-stage Parkinsons disease.
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