【摘 要】
：
Adulteration of herbal dietary supplements with synthetic antidiabetic drugs without labeling is illegal.Liquid chromatography (LC) coupled with mass spectrometry (MS) have been widely used for the an
【机 构】
：
Beijing National Laboratory for Molecular Sciences, Institute of Analytical Chemistry, College of Ch
【出 处】
：
第2届大连国际色谱学术报告会、第37届国际高效液相色谱及相关技术会议、第18届全国色谱学术报告会
论文部分内容阅读
Adulteration of herbal dietary supplements with synthetic antidiabetic drugs without labeling is illegal.Liquid chromatography (LC) coupled with mass spectrometry (MS) have been widely used for the analysis of synthetic drugs in herbal products.However, tens of minutes or even several hours are usually required for sample pretreatment and separation.It is definitely time-consuming for the routine screening of adulterants in large numbers of herbal products on the market.In this study, the direct analysis in real time (DART) source was coupled to quadruple time of flight mass spectrometry (QTOF MS) for the rapid screening of synthetic antidiabetic drugs adulterated in herbal dietary supplements.Seven widely used antidiabetic drugs, including glibenclamide, gliclazide, glipizide, gliquidone, metformin, nateglinide, and rosiglitazone, were selected in our study.The supplement sample was simply extracted with methanol/water by manually shaking several times and subsequently analyzed by DART-MS without chromatographic separation.The adulteration of synthetic drugs was confirmed by the accurate m/z values combined with the MS/MS data.
其他文献
Molecular dynamics simulations were performed to study interactions between atomic hydrogen and silicon carbon.In present study,we focus on the effect of the surface temperature on H interacting with
Three-dimensional and electromagnetic Particle-in-Cell/ Monte Carlo (PIC/MC) simulations are performed to investigate the breakdown process in an air-filled microwave waveguide with the VORPAL of Tech
In this paper.the degradation of Rhodamine B (RhB) induced by low temperature plasma which was generated in a localized zone under various conditions such as,the initial solution pH,current intensity,
用于产生负氢离子的PIG型离子源作为回旋加速器的内源得到了广泛的应用.离子源引出束流的性能参数将直接影响加速器的许多性能指标，在进行负氢束流初步引出测量实验中，束流强度的实验测量结果远远高于空间限制流的理论计算值.因此，种电屏蔽盒的直流束流引出测量方法被提出.本文阐述了电屏蔽盒直流束流引出测量的基本方法，束流轨迹的CST数值模拟以及束流引出测量实验结果.通过空间电荷限制流的“V”；定律”进行拟合，
Most current reports, investigating the potential of mixed-mode phases in HPLC, describe stationary phases containing both hydrophobic and anionic groups [1, 2], as well as both hydrophobic and cation
A method for determination of ten kinds of monosaccharides in Lycium barbarum polysaccharide was established using ICS-5000 Capillary IC-PAD system.Capillary scale ion chromatography brings multiple a
Poly(methacrylic acid-ethylene glycol dimethacrylate) monolithic capillary and high performance liquid chromatography was applied to analyze 7 parabens, including methyl paraben (MP), ethyl paraben (E
Aptamers are single stranded DNA (ssDNA) or RNA molecules artificially selected from randomly generated DNA libraries for their specific binding to the target.For protein target, the appropriate ssDNA
Plasticizer is commonly used in the plastic industry to weaken the force between plastic molecules and then improve the processing properties of plastics.Phthalate acid esters (PAEs), widely considere
Halenia elliptica D.Don belonged to the Gentianaceae family is commonly used as a Tibetan medicinal herb in the treatment of hepatitis and cholecystitis.It was reported for the first time that five xa