长脂肪侧链2,5-二酮哌嗪衍生物的设计、合成与抗肿瘤活性研究

来源 :2015年全国药物化学学术会议暨第五届中英药物化学学术会议 | 被引量 : 0次 | 上传用户：wyattwong

【摘要】

：

从类曲霉链轮丝菌(Streptoverticillium aspergilloides)中分离的次级代谢产物piperifizine A(N-甲基-3,6-双苯烯基-2,5-二酮哌嗪)对多药耐药肿瘤细胞的抗肿瘤化合物的具有增效作用1,其作用靶点为P-glycoprotein.

【作者】

：

廖升荣刘永宏

【机构】

：

中国科学院南海海洋研究所,中国科学院热带海洋生物资源与生态重点实验室,广东省海洋药物重点实验室,广东广州 510301

【出处】

：

2015年全国药物化学学术会议暨第五届中英药物化学学术会议

【发表日期】

：

2015年3期

【关键词】

：

2 5-二酮哌嗪衍生物长脂肪侧链抗肿瘤

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长脂肪侧链2,5-二酮哌嗪衍生物的设计、合成与抗肿瘤活性研究

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