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  5. Suppression of Akt/mTOR pathway Enhances (-)-Gossypol-induced Cytotoxicity in Androgen-Independent P

Suppression of Akt/mTOR pathway Enhances (-)-Gossypol-induced Cytotoxicity in Androgen-Independent P

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：D_boy85
【摘 要】
：
The natural BH3-mimetic (-)-gossypol is currently undergoing Phase Ⅱ-Ⅲ clinical trials forhuman prostate cancer and showing promising efficacy.Here we show that suppression of Akt/mTOR pathway by NVP-
【作 者】
：
Jiqin lian Zhenhong Ni Bin Wang Fengtian He 
【机 构】
：
Third Military Medical University
【出 处】
：
中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议
【发表日期】
：
2014年3期
【关键词】
：
(-)-Gosssypol NVP-BEZ235 
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The natural BH3-mimetic (-)-gossypol is currently undergoing Phase Ⅱ-Ⅲ clinical trials forhuman prostate cancer and showing promising efficacy.Here we show that suppression of Akt/mTOR pathway by NVP-BEZ235 significantly enhanced (-)-gossypol-induced eytotoxicityin androgen-independent prostate cancer cells (AI-PC cells) in vitro and in vivo.
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