2. 您的位置
3. 首页
4. 会议论文
5. Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepato

Suppression of miR-199a maturation by HuR is crucial for hypoxia-induced glycolytic switch in hepato

来源 :第十一次全国基因功能与表观遗传调控学术研讨会 | 被引量 : 0次 | 上传用户：madfox1108

【摘 要】

：

Glucose metabolic reprogramming is a hallmark of cancer.Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism

【作 者】

：

张凌飞 刘默芳 

【机 构】

：

中科院上海生科院生化细胞所分子生物学国家重点实验室,上海市岳阳路320号,200031,中国

【出 处】

：

第十一次全国基因功能与表观遗传调控学术研讨会

【发表日期】

：

2015年10期

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Glucose metabolic reprogramming is a hallmark of cancer.Cancer cells rapidly adjust their energy source from oxidative phosphorylation to glycolytic metabolism in order to efficiently proliferate in a hypoxic environment, but the mechanism underlying this switch is still incompletely understood.

其他文献

组蛋白巴豆酰化修饰酶体系及在转录调控中的潜在功能

大量的研究表明组蛋白乙酰化修饰在转录、DNA损伤修复和DNA复制等过程中起着重要作用.近年来研究表明除了乙酰化之外,组蛋白还能发生一系列类乙酰化修饰如丙酰、丁酰、巴豆酰

会议

室性心律失常的神经调控治疗

　　室性心律失常是临床上最常见的心律失常，严重影响着人们的健康和生活质量，药物、经皮导管射频消融和植入器械只能治疗部分患者，多形性室性心动过速、心室颤动等恶性室性心律

会议

心律失常神经调控

Uracil-DNA glycosylase UNG promotes Tet-mediated DNA demethylation

In mammals, active DNA demethylation involves oxidation of 5-methylcytosine (5mC) into 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) by Tet dioxygenases

会议

Suppression of enhancer over-activation by a RACK7-histone demethylase complex

Primed enhancers are marked by histone H3K4 mono-methylation (H3K4me1), and the conversion to active enhancers involves acetylation of histone H3K27 (H3K27Ac).

会议

The regulation of anti-viral signaling pathway by WDR82,a subunit of H3K4 methyltransferase complex

Upon virus infection, RIG-I-like receptors in host cells recognize viral RNA and activate type Ⅰ interferon expression.

会议

microRNAs调控大脑皮层层次决定

大脑皮层层次形成受到十分精确的时空表达调控,是通过神经干细胞精细的增殖与分化来实现的.以小鼠大脑皮层层次形成为例,神经干细胞从E10.5天到E16.5天,基本上每天生成不同类

会议

Structural insight into substrate preference for TET-mediated oxidation

TET proteins iteratively oxidize 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC).

会议

Control of non-homologous end joining by histone H2AX

Phosphorylated histone H2AX, also termed γH2AX, mediates the chromatin response to DNA double strand break (DSBs) in mammalian cells and assists DSB repair.

会议

The role and mechanism of Vigilin in maintaining the stability and function of pericentromeric heter

Vigilin, a multi-KH-domain protein, participates in heterochromatin formation.CCCTC-binding factor (CTCF) has been implicated in numerous aspects of chromosome

会议

The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate

　　The Mediator complex orchestrates multiple transcription factors with the Pol Ⅱ apparatus for precise transcriptional control.However, its interplay with t

会议

H2B mono-ubiquitinationmyogenesisMediator MED23RNF20 and RNF40tumorigenesis