Tanshinone Ⅱ-A sodium sulfonate (DS-201) enhances the activity, expression and trafficking of BKCa c

来源 :中国生理学会第24届全国会员代表大会暨生理学学术大会 | 被引量 : 0次 | 上传用户:lucylxh
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  Aim:Tanshinone Ⅱ-A sodium sulfonate (DS-201),a derivative of salvia miltiorrhiza,could activate BKCa channels and induce vascular relaxation,but the underlying mechanisms are unknown.The present 1βstudy aimed to address this issue.Methods:BKCa channel α subunit,or plus subunit,were expressed in HEK293 cells by transfecting plasmids pcDNA3.1-hSlo,Flag-hSlo-EGFP,or with pEF1-myc-hβ1,respectively.
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