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EphA2 is a transmembrane receptor tyrosine kinase that is highly expressed on both tumor neovasculature and some kinds of tumor cells.Here, a homing peptide with a sequence of YSAYPDSVPMMSK (YSA) that binds specifically with EphA2 was utilized to modify the stealth liposomes (YSA-LP).With a particle size of about 85 nm, this functionalized nanocarrier was loaded with fluorescent probe or do xo rub ic in (DOX) and investigated in vitro and in vivo.