【摘 要】
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Long noncoding RNAs(lncRNA)participate in carcinogen-esis and tumor progression in lung cancer.Here,we report the identification of a lncRNA signature associated with metastasis of non-small cell lung
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Long noncoding RNAs(lncRNA)participate in carcinogen-esis and tumor progression in lung cancer.Here,we report the identification of a lncRNA signature associated with metastasis of non-small cell lung cancer(NSCLC).In partic-ular,elevated expression of LINC00963(MetaLnc9)in human NSCLC specimens correlated with poor prognosis,promoted migration and invasion of NSCLC cells in vitro,and enhanced lung metastasis formation in vivo.Mechanistic investigations showed that MetaLnc9 interacted with the glycolytic kinase PGK1 and prevented its ubiquitination in NSCLC cells,lead-ing to activation of the oncogenic AKT/mTOR signaling pathway.MetaLnc9 also interacted with P54nrb/NonO(NONO)to help mediate the activity of CRTC,a coactivator for the transcription factor CREB,reinforcing a positive feed-back loop for metastasis.Taken together,our results establish MetaLnc9 as a driver of metastasis and a candidate therapeu-tic target for treating advanced NSCLC.
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