Gene therapy is a promising approach to treat various human genetic and acquired diseases.Extensive efforts have been explored to increase gene transfection efficiency and low toxicity through rational design of degradable and multifunctional polymeric vectors overcoming various transfection barriers.However,it is very challenging to generate a multifunetional polymer conjugates with all rationally designed components.Our strategy is to construct a modular approach to form the supramolecular self-assembly of beta-cyclodextrin-based polymer (PBCD) and many monoadamantane-terminated functionalized polymers via host-gnest interaction for complexing plasmid DNA or siRNA into nanoparticles (Scheme 1).