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Objective:We have identified,by a monoclonal anti-idiotypic antibody (Mab2-5G2) which functionally mimics PRRSV GP5 protein,non-muscle myosin heavy chain Ⅱ-A (NMHC Ⅱ-A) as a novel cellular receptor on Marc-145 cells and porcine alveolar macrophages (PAM) for PRRSV.The functional domain in NMHC Ⅱ-A has been identified at its C-terminus and the corresponding recombinant protein (designated PRA) was produced.The objective of this study was to investigate the role of PRA in PRRSV infection in Marc-145 cells stably expressing exogenous PRA gene (GenBank No.HM490008).