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There is limited experience in treating infective endocarditis (IE) with outpatient parenteral antibiotic therapy.Following IRB study approval, patients discharged from Baystate Medical Center with IE documented by modified Duke criteria treated with OPAT were identified.Data obtained included percentage of total therapy rendered after hospitalization,and one year follow-up.Forty-four patients met criteria.Thirty-five percent of patients were infected with staphylococci;38% harbored streptococci or enterococci.