【摘 要】
：
Neuroinflammation and oxidative stress is involved in many human neuroimmunodegenerative diseases,including the human immunodeficiency virus disease/AIDS,multiple sclerosis,Alzheimers disease,amyotrop
【机 构】
：
Northwestern University,Feinberg School of Medicine,303 East Superior Street Lurie 8-250 Chicago,IL
【出 处】
：
2006中国天津世界艾滋病日科技会议
论文部分内容阅读
Neuroinflammation and oxidative stress is involved in many human neuroimmunodegenerative diseases,including the human immunodeficiency virus disease/AIDS,multiple sclerosis,Alzheimers disease,amyotrophic lateral sclerosis (ASL),and Parkinsons disease.In our model of H1V-associated dementia (HAD),FVB/N mice are infected with a neuroimmunopathogenic mutant of the Moloney murine Leukemia Virus (MoMuLV) ts1,which causes progressive neuroimmunodegeneration similar to that of HAD patients.In the central nervous system (CNS),both HIV and ts 1 infect endothelial cells,microglia,and astrocytes,causing an inflammatory response from these cell types.
其他文献
Chinese Tea,pomegranate juice and extract of trifolium are some of the promising sources of antivirals from the Asian and African continent.In order to harness this sources and develop therapeutic rem
Since 1996,the optimization of antiretroviral therapy has led to great improvements in both the quality of life and life expectancy of people living with HIV/AIDS,at least in countries where HAART is
HIV-1 cell entry is a multi-step process that is an attractive target for the development of new classes of therapeutic agents.HIV-1 cell entry inhibitors include a variety of drugs with different poi
Pneumocystisjiroveci (formerly carinii) pneumonia (PCP) is still a common AIDS-defining disease and cause of mortality in HIV-infected persons.Conventional treatments,trimethoprim-sulfamethoxazole (Tm
For many years I have asked the same question as a nurse educator,why atter so many years of funding Government and Non-Government projects to address HIV/AIDS,many countries are facing a pandemic.My
A new strategy ofpeptide reagent design,namely AABPD (amino acid based-peptide design),especially for HIV peptide fusion inhibitors,is proposed based on the physical and chemical properties of amino a
Acquired immune deficiency syndrome (AIDS) is caused by the infection of human immunodeficiency virus (HIV)and last centrry witnessed the boom of AIDS/HIV patients especially in less developed countri
Object:To search new water-soluble active chemical component from Salvia yunnanensis and to study its antiHIV-1 activity in vitro.Methods:Compounds were isolated and purified by Diaion HP20,Sephadex H
Background:Enfuvirtide (T20),a fusion inhibitor derived from the C-terminal heptad repeat region (CHR) of HIV-1 gp41 is the only peptidic anti-HIV drug licensed by the US FDA.However,concerns have bee