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  5. Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis

Identifying cis-mediators for trans-eQTLs across many human tissues using genomic mediation analysis

来源 :上海交通大学 | 被引量 : 0次 | 上传用户：fuiegfiusbkufbakuefg
【摘 要】
：
The impact of inherited genetic variation on gene expression in humans is well-established.The majority of known expression quantitative trait loci(eQTLs)impact expression of local genes(cis-eQTLs); m
【作 者】
：
Fan Yang Jiebiao Wang the GTEx consortium Brandon L.Pierce Lin S.Chen 
【机 构】
：
Department of Public Health Sciences,University of Chicago,60637,USA
【出 处】
：
上海交通大学
【发表日期】
：
2016年4期
【关键词】
：
expression quantitative trait loci (eQTL) trans-eQTL cis-eQTL genomic mediation 
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论文部分内容阅读
　　The impact of inherited genetic variation on gene expression in humans is well-established.The majority of known expression quantitative trait loci(eQTLs)impact expression of local genes(cis-eQTLs); more research is needed to identify effects of genetic variation on distant genes(transeQTLs)and understand the biological mechanisms.
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