在制药公司研发新药的过程中，建立新药的剂量与病人反应的关系是一项很重要的工作。对新药剂进行的临床试验大体可以分为三个阶段。......

Phase Ⅰ designs traditionally use the dose-limiting toxicity(DLT),a binary endpoint based on the first treatment cycle,......

One of the main purposes of a phase dose-finding trial in oncology is to identify a tolerable dose with an indication of......

The primary objective of cancer phase Ⅰ studies is to determine the maximum tolerated dose(MTD)....

Background: Phase trials are designed to determine the safety,tolerability and recommended phase 2 dose of therapeutic a......

In oncology area,following a phase Ⅰ dose-finding trial completed in a certain population of patients,further phase Ⅰ ......

Objective:The recommended dose of prophylactic pegylated recombinant human granulocyte-colony stimulating factor (PEG rh......

目的：研究新药安全性指标和有效性指标为计数数据以及相关条件下的联合评价及剂量选择问题。方法：基于阿基米德Copula性质建立了双计......

A dose-finding study was performed with respect to the clinical applicability and tolerability of three different concen......

剂量寻找(dose-finding)方法在临床试验第Ⅱ阶段中发挥着重要作用。找到一个适合的剂量寻找方法可以节省大量的时间和资金。在一众......