【摘 要】
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Background: Parkinson's disease(PD) is a neurodegenerative disease.With the progress of the disease, the symptoms gradually worse and levodopa-induced motor
【机 构】
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Department of Neurology, First Affiliated Hospital, Sun Yat-sen University,Guangdong Key Laboratory
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Background: Parkinson's disease(PD) is a neurodegenerative disease.With the progress of the disease, the symptoms gradually worse and levodopa-induced motor complication arise.Deep brain stimulation(DBS) is an effective treatment for advanced PD.There are some RCT researches for short term efficacy for DBS as well as some long term study in foreign.But its long term efficacy have been little formulated in China, although China occupies the largest proportion of PD patients.Objective: To investigate the long term efficacy and its safety of STN DBS for PD in China with an eight years follow up of nine patients.Methods: Patients with PD who had recieved bilateral STN DBS, was assessed preoperatively(baseline) and 1, 3, 5 and 8 years postoperatively on medication and without medication, using the Unified Parkinson's disease Rating Scale (UPDRS) and a series of neruopsychological assessment.At the same time, the levodopa equivalent daily dose (LEDD) and stimulating parameter were also recorded.
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