Hyperlipidemia is a common risk factor for cardiovascular disease (CVD) and is associated with insulin resistance and obesity.Cytochrome P450 (CYP) epoxygenases convert arachidonic acid to four epoxyeicosatrienoic acids (EETs) that exert diverse biological effects in cardiovascular and metabolic tissues;however, it is unknown whether these enzymes or their metabolites play any roles in hyperlipidemia.