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Nemacystus Decipiens is a brown seweed which grows on Okinawa Island and is widely used as a kind of food.However, the structure and bioactivity of polysaccharides from Nemacystus Decipiens were less reported.Here, a crude polysaccharide, named as NDH, was isolated from Nemacystus Decipiens by hot water extraction, and the mainly fraction NDH8S was further purified by a DEAE-Cellulose column.