TNF-α在骨质疏松性疼痛中的作用

来源 :2010广东省医学会骨科年会暨岭南骨科学术大会 | 被引量 : 0次 | 上传用户：underdog1234

【摘要】

：

【作者】

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黎艺强陈柏龄谢登辉

【机构】

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中山大学附属第一医院脊柱外科

【出处】

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2010广东省医学会骨科年会暨岭南骨科学术大会

【发表日期】

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2010年4期

【关键词】

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骨质疏松性疼痛肿瘤坏死因子α 疼痛行为测量免疫组织化学

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　　目的探讨肿瘤坏死因子α(TNF-α)在骨质疏松性疼痛中的作用.方法 40只5月龄Sparague-Dawley(S D)雌性大鼠随机分为假手术组(Sham,1 6只)和去卵巢组(Ovx,24只).Ovx术后第5周开始应用上下法(Up-down method)和撤尾法(Tail withdraw test)对两组大鼠进行疼痛行为测量,每周1次.术后第8周每组分别杀死8只大鼠,取腰5背根神经节,用免疫荧光方法检测腰5背根神经节中TNF-α的表达.Ovx组剩余的16只大鼠再随机分成Ovx-1组和Ovx-2组,其中Ovx-2组予腹腔注射TNF-α合成抑制剂沙利度胺(50 mg/kg,1次/天)；Ovx-1组和Sham组则分别注射等量的生理盐水.

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TNF-α在骨质疏松性疼痛中的作用

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