Objective: To discuss the minimally invasive treatment and prognosis of juvenile nasopharyngeal angiofibroma(JNA) involving the eye and optic nerve.Methods: A retrospective analysis of the clinical data for 18 large JNAs and on the reports of three typical cases.Results: The tumour invaded the orbit,eye, optic nerve and optic chiasm of 18,9, 8 and 5 patients, respectively.Twelve patients were cured after surgery with the affected eye and vision essentially returning to normal.In six JNAs, tumour residue was found in the middle cranial fossa.Two of six patients did not return for follow-up,and four underwent radiotherapy.All four patients regained placement of the eye in the normal or near-normal position.One patient regained normal visual acuity, whereas three patients experienced no improvement in visual acuity, with one of them becoming blind.Conclusions: Surgery may return the eye to the normal position and may restore visual acuity if the optic fundus,macula, retina and optic nerve are only mildly affected.Modern radiotherapy can treat the intracranial residue effectively.A combined antrum-infratemporal fossa-nasal cavity approach via a Caldwell-Luc incision provides a minimally invasive method.