BLOCKADE OF B CELLS IN HBV PATIENTS WITH PRE-EXISTING IFNR SIGNALING HAVE IMPROVED EFFECT DURING IFN

来源 :The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会) | 被引量 : 0次 | 上传用户：dh9998

【摘要】

：

【作者】

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Binqing Fu Dongyao Wang Rui Sun Zhigang Tian Haiming Wei

【机构】

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Institute of Immunology, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Li

【出处】

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The 1st NI-CMI Joint Conference(第一届CMI-NI免疫学国际研讨会)

【发表日期】

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2015年11期

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Type Ⅰ interferons are critical for antiviral immunity and have been widely used in the treatment of HBV and HCV-related hepatitis.However, distinct from HCV, IFN treatments of HBV do not obtain the expected effect.We demonstrated that induced persistent IFNαR signaling is mainly up-regulated on regulatory B cells but not on T cells during IFNα treatment.

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BLOCKADE OF B CELLS IN HBV PATIENTS WITH PRE-EXISTING IFNR SIGNALING HAVE IMPROVED EFFECT DURING IFN

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