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Background To observe the changes of myocardial performance index (Tei index) and plasma atrial natriuretic peptide(ANP), brain natriuretic peptide (BNP) in patients with patent ductus arteriosus (PDA) treated by trans-catherter closure,and identify its associated factors.Methods Twenty-four patients with PDA underwent trans-catheter closure using occluder, the Tei index of left and right ventricular were measured with echocardiograph before and after trans-catheter closure at 2 days and 3 months respectively.The plasma concentration of ANP and BNP were measured before and after closure at 10 minutes, 2 days and 3 months.