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目的评价熊去氧胆酸(UDCA)治疗妊娠期肝内胆汁淤症(ICP)的效果。方法86例患者,随机分成两组。治疗组46例,采用UDCA250mg,每日3次口服;对照组40例,予能量合剂500ml静滴,每日1次,两组均以10天为1个疗程,观察疗效。结果使用UDCA治疗ICP,不仅改善患者临床症状和血生化异常,还可延长ICP患者胎儿孕龄,减少胎儿窒息和新生儿窘迫的发生。结论UDCA是治疗ICP安全、有效的药物。
Objective To evaluate the efficacy of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy (ICP). Methods Totally 86 patients were randomly divided into two groups. Treatment group, 46 cases, UDCA250mg, 3 times a day orally; control group of 40 patients, 500ml intravenous infusion of energy mixture, once a day, both groups were 10 days for a course of treatment to observe the effect. Results UDCA treatment of ICP, not only to improve the patient’s clinical symptoms and blood biochemical abnormalities, but also extend the fetus gestational age patients with ICP, reduce fetal asphyxia and neonatal distress. Conclusion UDCA is a safe and effective drug for the treatment of ICP.