【摘 要】
：
Hypertrophic scarring (HS) is a pathological wound healing process,which is mainly due to the abnormal metabolism of collagen and excessive microvessel formation.Generally,this process reaches a peak
【机 构】
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Orthopedic Insatute,Soochow University,Suzhou 215007,China;Department of Plastic and Reconstructive
【出 处】
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The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Hypertrophic scarring (HS) is a pathological wound healing process,which is mainly due to the abnormal metabolism of collagen and excessive microvessel formation.Generally,this process reaches a peak in the three months after wound healing.Currently,the main method for treating hypertrophic scar is injection steroid with 5-FU.However,multiple injections would bring more pain to the patients and excessive steroid and 5-FU will cause some side effects [1].Previously,we fabricated Rg3-1oaded PLGA electrospun fibrous scaffolds and carried out in situ implantation in the rabbit ear scar model for treating HS [2].Although our study found that these scaffolds could inhibit angiogenesis and fibroblast cell growth through one-time implantation,these drug-loaded scaffolds could not achieve long-term release of Rg3 for inhibiting HS.
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