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Polymersomes are one of the most ideal systems for intracellular delivery of water-soluble apoptotic drugs including low molecular weight chemotherapeutics and protein drugs [1].Here,we report on anisamide-functionalized reduction-sensitive reversibly crosslinked polymersomes (Anis-PS) for targeted delivery of methotrexate (MTX) to H460 lung cancer cells.Anis-PS was prepared from anisamide-poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl)methacrylamide-g-lipoic acid)-b-poly-2-(dimethyl amino)ethyl methacrylate (Anis-PEG-P(HPMA-LA)-PDMA) and non-targeting PEGP(HPMA-LA)-PDMA copolymers.