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  5. Anisamide-functionalized intelligent polymersomes mediate targeted delivery of methotrexate into lun

Anisamide-functionalized intelligent polymersomes mediate targeted delivery of methotrexate into lun

来源 :The Third Symposium on Innovative Polymers for Controlled De | 被引量 : 0次 | 上传用户：cyh
【摘 要】
：
Polymersomes are one of the most ideal systems for intracellular delivery of water-soluble apoptotic drugs including low molecular weight chemotherapeutics and protein drugs [1].Here,we report on anis
【作 者】
：
Weijing Yang Fenghua Meng Zhiyuan Zhong 
【机 构】
：
Biomedical Polymers Laboratory,and Jiangsu Key Laboratory of Advanced Functional Polymer Design and
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
【发表日期】
：
2014年6期
【关键词】
：
polymersomes tumor-targeting reversibly crosslinking reduction-sensitive 
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　　Polymersomes are one of the most ideal systems for intracellular delivery of water-soluble apoptotic drugs including low molecular weight chemotherapeutics and protein drugs [1].Here,we report on anisamide-functionalized reduction-sensitive reversibly crosslinked polymersomes (Anis-PS) for targeted delivery of methotrexate (MTX) to H460 lung cancer cells.Anis-PS was prepared from anisamide-poly(ethylene glycol)-b-poly(N-(2-hydroxypropyl)methacrylamide-g-lipoic acid)-b-poly-2-(dimethyl amino)ethyl methacrylate (Anis-PEG-P(HPMA-LA)-PDMA) and non-targeting PEGP(HPMA-LA)-PDMA copolymers.
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