【摘 要】
：
背景:森林脑炎是由蜱传脑炎病毒(TBEV)引起的可造成中枢神经系统感染的疾病,目前中枢神经系统损失的机理尚不完全清楚.基质蛋白酶MMP-9及炎症因子IL-6等有可能在血脑屏障破坏及TBEV致病过程中发挥了重要作用.方法:在中国东北地区我们收集了72份TBE病人的脑脊液标本,用ELISA方法检测了血清及脑脊液中TBEV的特异性抗体、MMP-9水平及IL-6的表达水平.对MMP-9的表达增高与炎症反应
【机 构】
：
病原微生物生物安全国家重点实验室,北京,100071 牡丹江林业中心医院
论文部分内容阅读
背景:森林脑炎是由蜱传脑炎病毒(TBEV)引起的可造成中枢神经系统感染的疾病,目前中枢神经系统损失的机理尚不完全清楚.基质蛋白酶MMP-9及炎症因子IL-6等有可能在血脑屏障破坏及TBEV致病过程中发挥了重要作用.方法:在中国东北地区我们收集了72份TBE病人的脑脊液标本,用ELISA方法检测了血清及脑脊液中TBEV的特异性抗体、MMP-9水平及IL-6的表达水平.对MMP-9的表达增高与炎症反应、抗体渗漏及疾病严重性的关系分别进行了统计分析.
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