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目的探讨关类风湿节炎(RA)患者血清MMP-2和MMP-9浓度变化及其临床价值。方法 RA患者73例,将病例分成活动期RA组(n=43)和缓解期RA组(n=30)两组,骨关节炎(OA)组34例,健康对照组46例,用ELISA测定各组MMP-2和MMP-9水平,描绘受试者工作曲线(ROC)并进行曲线下面积(AUC)曲线分析。结果 RA组血清MMP-2水平和血清MMP-9水平均显著高于对照组(P<0.01)及OA组(P<0.05);活动期RA组MMP-2和MMP-9均显著高于缓解期RA组(P<0.05)。MMP-2诊断活动期RA的AUC为0.808,MMP-9诊断活动期RA的AUC为0.843,临界值分别为479.9 ng/ml和698.3 ng/ml;MMP-2诊断RA的AUC为0.733,MMP-9诊断RA的AUC为0.760,临界值分别为153.9 ng/ml和197.8 ng/ml,两项联合诊断RA的AUC为0.878。结论 MMP-2和MMP-9对RA的诊断均具有较好的诊断和鉴别诊断价值,两者联合更利于RA的诊断和病情评估。
Objective To investigate the changes of serum MMP-2 and MMP-9 levels in patients with rheumatoid arthritis (RA) and their clinical value. Methods Totally 73 RA patients were divided into two groups: active RA group (n = 43) and remission RA group (n = 30), 34 cases of osteoarthritis (OA) group and 46 healthy control group The levels of MMP-2 and MMP-9 in each group were plotted and the receiver operating characteristic curve (ROC) was plotted and the area under the curve (AUC) curve was analyzed. Results Serum levels of MMP-2 and serum MMP-9 in RA group were significantly higher than those in control group (P <0.01) and OA group (P <0.05). MMP-2 and MMP-9 in RA group were significantly higher than those in control group RA group (P <0.05). The AUC of MMP-2 in active RA was 0.808, the AUC of active RA was 0.843 in MMP-9, the cut-off values were 479.9 ng / ml and 698.3 ng / ml, respectively. The AUC of MMP- The diagnostic AUC of RA was 0.760 with a cut-off value of 153.9 ng / ml and 197.8 ng / ml, respectively. The AUC of the two combined diagnoses was 0.878. Conclusions Both MMP-2 and MMP-9 are valuable in the diagnosis and differential diagnosis of RA. The combination of MMP-2 and MMP-9 is beneficial to the diagnosis and assessment of RA.