【摘 要】
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Fibroblast growth factors (FGFs) modulate ovarian function, including FGF8 and FGF18.These FGFs activate the same receptors, although FGF18 is unusual in that it increases apoptosis in ovarian granulo
【机 构】
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College of Animal Science and Technology, Northwestern Agricultural and Forestry University, Yanglin
【出 处】
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第二届中国肉牛选育改良与产业发展国际研讨会暨中国畜牧兽医学会养牛分会八届二次学术研讨会
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Fibroblast growth factors (FGFs) modulate ovarian function, including FGF8 and FGF18.These FGFs activate the same receptors, although FGF18 is unusual in that it increases apoptosis in ovarian granulose cells whereas the typical response to FGF is increased proliferation.The objective of the present study was to determine which early response genes and pathways are activated by FGF8 and FGF18 in bovine granulosa cells.FGF8 increased abundance of mRNA encoding the FGF-responsive genes SPRY1, SPRY2, SPRY4, NR4A1 and NR4A3 whereas FGFI8 did not.FGF8 increased but FGF18 decreased levels of mRNA encoding the growth arrest associated protein, GADD45B.FGF8 increased ERK1/2 phosphorylation butFGF 18 did not.Microarray analysis identified EGR1, FOS, FOSL 1, BAMBI, X1RP 1 and PLK2 as other FGF8immediate-early response genes, and FGF18 stimulated EGRI, FOSL1, BAMBI and PLK2, but not FOS or XIRP1.This study demonstrates that FGF8 and FGF18 signal through divergent pathways in ovarian granulosa cells, despite reportedly similar receptor activation patterns.
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